rs11196181 - TCF7L2
Magnitude 2.2 · 1 study on file
Reported associations
-
Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484
ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
-
HbA1c levels High
TCF7L2 rs11196181 risk allele associated with elevated HbA1c, a marker of long-term glycemic control
Every 6-12 months or per healthcare provider guidance
Discuss with your doctor
-
genetic risk factor for type 2 diabetes High
TCF7L2 rs11196181 is a validated genetic risk factor for dysglycemia with strong population-level evidence
Screening
-
type 2 diabetes screening or earlier evaluation High
TCF7L2 is a genome-wide significant locus for glycemic regulation; risk allele carriers show elevated HbA1c
Discuss timing and frequency with healthcare provider