rs11196086 - VTI1A

Magnitude 2.2 · 1 study on file

Reported associations

• Non-coding genetic elements of lung cancer identified using whole genome sequencing in 13,722 Chinese - Unknown journal (n.d.) · Unknown authors · PubMed 40783572

  ABSTRACT: A substantial portion of lung cancer-associated genetic elements in East Asian populations remains unidentified, underscoring the need for large-scale genome-wide studies, particularly on non-coding regulation. We conducted a whole genome sequencing (WGS)-based genome-wide scan in 13,722 Chinese individuals to identify regulatory elements associated with lung cancer. We verified common-variant-based loci by meta-analysis across the available East Asian studies. Integrating a genome-transcriptome reference panel of lung tissue in 297 Chinese, we bridged the variant-lung cancer associations, highlighting genes including TP63 and DCBLD1. Implementing the STAAR pipeline for rare variant aggregate analysis, we identified and replicated novel genes, including PARPBP, PLA2G4C, and RITA

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