rs11195238 - SMC3 - Y_RNA

Magnitude 4.5 · 1 study on file

Reported associations

• Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study - Unknown journal (n.d.) · Unknown authors · PubMed 31982041

  ABSTRACT: Background. The acute respiratory distress syndrome (ARDS) is a lung inflammatory process mainly caused by sepsis. Most previous studies that identified genetic risks for ARDS were focused on biological candidates. We aimed to identify novel genetic variants associated with ARDS susceptibility and to provide complementary functional evidence. Methods. We conducted a case-control genome-wide association study (GWAS) in 1,935 European subjects, using sepsis-associated ARDS patients as cases and sepsis patients without ARDS as controls. The discovery stage included 672 patients admitted into a network of Spanish intensive care units. The replication stage comprised 1,345 individuals from two independent datasets involving the MESSI cohort study (U.S.A.) and the VISEP/MAXSEP trials o

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