rs1119251 - NEO1
Magnitude 4.5 · 1 study on file
Reported associations
-
Genome-wide association meta-analysis identifies two novel loci associated with dental caries. - BMC oral health (2024) · Nogawa S, Morishita S, Saito K, Kato H · PubMed 39192244
Tooth loss significantly impacts oral function and overall health deterioration. Dental caries and periodontal disease are major contributors to tooth loss, emphasizing the critical need to prevent these conditions. Genetic studies have played a crucial role in deepening our understanding of the underlying mechanisms of these diseases. While large-scale genome-wide association studies (GWAS) on dental caries and periodontal disease have been conducted extensively, research focusing on Asian populations remains limited. Given substantial genetic and lifestyle variations across ethnicities, conducting studies across diverse populations is imperative. This study aimed to uncover new insights into the genetic mechanisms of these diseases, contributing to broader knowledge and potential targete
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
-
limit sugary and acidic foods Moderate
genetic caries susceptibility demands dietary caution; sugar and acids directly promote caries
Lifestyle
-
daily oral hygiene routine Moderate
genetic predisposition to dental caries requires heightened preventive measures
brush 2-3 times daily, daily flossing, fluoride rinse
Screening
-
dental screening every 3-4 months Moderate
rs1119251-T allele increases dental caries risk via NEO1 expression effects in oral tissues