rs11191667 - TAF5
Magnitude 2.2 · 1 study on file
Reported associations
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High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study - Unknown journal (n.d.) · Unknown authors · PubMed 35762941
ABSTRACT: Purpose To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma. Methods Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. To evaluate the BP versus primary open-angle glaucoma (POAG) relationship, additional Mendelian randomization (MR) analyses were conducted using published GWAS summary statistics. Results Observational analysis revealed a linear relationship between BP traits and IOPcc, with a +0.28 mm Hg increase in IOPcc per 10-mm Hg inc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to hypertension Moderate
GWAS study demonstrates rs11191667 risk allele association with elevated systolic blood pressure, enabling personalized risk assessment and preventive strategies
Discuss with healthcare provider about genetic blood pressure risk and monitoring options
Screening
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systolic blood pressure monitoring Moderate
rs11191667 risk allele (A) is associated with elevated systolic blood pressure; approximately 0.32 mmHg increase per risk allele
Annual screening if normotensive; 6-12 month intervals if borderline or elevated