Expressive

rs111901638 - SIK3

Magnitude 2.2 · 2 studies on file

Reported associations

  • Impact of polygenic risk score for triglyceride trajectory and diabetic complications in subjects with type 2 diabetes based on large electronic medical record data from Taiwan: a case control study. - Journal of endocrinological investigation (2024) · Liao WL, Huang YC, Chang YW, Cheng CF, Liu TY, Lu HF, Chen HL, Tsai FJ · PubMed 38795312

    The prevalence of diabetic dyslipidemia has gradually increased worldwide and individuals with hypertriglyceridemia often have a high polygenic burden of triglyceride (TG)-increasing variants. However, the contribution of genetic variants to dyslipidemia in patients with type 2 diabetes (T2D) remains limited. Therefore, in this study, we aimed to investigate the genetic characteristics of longitudinal changes in TG levels among patients with T2D and summarize the genetic effects of polygenic risk score (PRS) on TG trajectory and risk of diabetic complications. We conducted a case-control study. A total of 11,312 patients with T2D with longitudinal TG and genetic data were identified from a large hospital database in Taiwan. We then performed a genome-wide association study and calculated t

  • A Genome-Wide Association Study of Metabolic Syndrome in the Taiwanese Population - Unknown journal (n.d.) · Unknown authors · PubMed 38201907

    ABSTRACT: The purpose of this study was to investigate genetic factors associated with metabolic syndrome (MetS) by conducting a large-scale genome-wide association study (GWAS) in Taiwan, addressing the limited data on Asian populations compared to Western populations. Using data from the Taiwan Biobank, comprehensive clinical and genetic information from 107,230 Taiwanese individuals was analyzed. Genotyping data from the TWB1.0 and TWB2.0 chips, including over 650,000 single nucleotide polymorphisms (SNPs), were utilized. Genotype imputation using the 1000 Genomes Project was performed, resulting in more than 9 million SNPs. MetS was defined based on a modified version of the Adult Treatment Panel III criteria. Among all participants (mean age: 50 years), 23% met the MetS definition. GW

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • fasting triglyceride levels Moderate

    SIK3 rs111901638 risk allele associates with elevated triglyceride trajectory in type 2 diabetes

    Annual or bi-annual measurement

Diet

  • dietary fiber and whole grains Moderate

    Fiber reduces triglyceride synthesis and improves insulin sensitivity, mitigating elevated trajectory risk

    Target 25-35g fiber daily; 75%+ of grains from whole grain sources

  • refined carbohydrates Moderate

    Refined carbs exacerbate triglyceride elevation, particularly problematic for risk allele carriers

    Limit to <15% of daily calories

Discuss with your doctor

  • triglyceride management strategy Moderate

    Elevated triglyceride trajectory may warrant medical assessment and potential pharmacotherapy beyond lifestyle modification

Exercise

  • aerobic exercise Moderate

    Regular aerobic activity reduces triglycerides and improves insulin sensitivity, critical for managing elevated trajectory

    150 minutes moderate-intensity aerobic activity per week