Expressive

rs11187007 - IDE

Magnitude 2.2 · 1 study on file

Reported associations

  • Genotyping and population characteristics of the China Kadoorie Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 37601966

    ABSTRACT: Summary The China Kadoorie Biobank (CKB) is a population-based prospective cohort of >512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across China. Detailed data from questionnaires and physical measurements were collected at baseline, with additional measurements at three resurveys involving ∼5% of surviving participants. Analyses of genome-wide genotyping, for >100,000 participants using custom-designed Axiom arrays, reveal extensive relatedness, recent consanguinity, and signatures reflecting large-scale population movements from recent Chinese history. Systematic genome-wide association studies of incident disease, captured through electronic linkage to death and disease registries and to the national health insurance system, replicate est

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Type 2 diabetes risk stratification and prevention plan Moderate

    Genetic risk at this locus warrants personalized risk assessment and counseling from healthcare provider for targeted intervention

Exercise

  • Regular aerobic and resistance exercise Moderate

    Physical activity improves insulin sensitivity and glucose metabolism; particularly important for T2D genetic risk carriers

    150 minutes per week moderate aerobic plus 2 sessions per week resistance training

Lifestyle

  • Maintain healthy weight (BMI 18.5-24.9 kg/m2) Moderate

    Obesity significantly increases Type 2 diabetes risk in genetically predisposed carriers; weight loss reduces disease progression risk

    Calculate BMI; target 5-10% weight loss if overweight; consider dietitian referral

Screening

  • Type 2 diabetes screening baseline and periodic Moderate

    rs11187007 risk allele (A) associates with 16.7% increased Type 2 diabetes odds via beta cell function genes including HHEX; early detection enables intervention

    Fasting glucose or HbA1c at baseline, repeat every 3 years if normal