rs11186609 - LINC02655 - RPS7P9

Magnitude 2.2 · 1 study on file

Reported associations

• Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines - Unknown journal (n.d.) · Unknown authors · PubMed 30053915

  ABSTRACT: Background Humoral immune responses to infectious agents or vaccination vary substantially among individuals, and many of the factors responsible for this variability remain to be defined. Current evidence suggests that human genetic variation influences (i) serum immunoglobulin levels, (ii) seroconversion rates, and (iii) intensity of antigen-specific immune responses. Here, we evaluated the impact of intrinsic (age and sex), environmental, and genetic factors on the variability of humoral response to common pathogens and vaccines. Methods We characterized the serological response to 15 antigens from common human pathogens or vaccines, in an age- and sex-stratified cohort of 1000 healthy individuals (Milieu Intérieur cohort). Using clinical-grade serological assays, we measured

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