rs1118438 - RN7SL602P - SMIM7P1

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide host-pathogen analyses reveal genetic interaction points in tuberculosis disease - Unknown journal (n.d.) · Unknown authors · PubMed 36725857

  ABSTRACT: The genetics underlying tuberculosis (TB) pathophysiology are poorly understood. Human genome-wide association studies have failed so far to reveal reproducible susceptibility loci, attributed in part to the influence of the underlying Mycobacterium tuberculosis (Mtb) bacterial genotype on the outcome of the infection. Several studies have found associations of human genetic polymorphisms with Mtb phylo-lineages, but studies analysing genome-genome interactions are needed. By implementing a phylogenetic tree-based Mtb-to-human analysis for 714 TB patients from Thailand, we identify eight putative genetic interaction points (P < 5 × 10−8) including human loci DAP and RIMS3, both linked to the IFNγ cytokine and host immune system, as well as FSTL5, previously associated

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