Expressive

rs111831594 - KANK2

Magnitude 2.2 · 1 study on file

Reported associations

  • Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank. - Nature genetics (2024) · Oliveri A, Rebernick RJ, Kuppa A, Pant A, Chen Y, Du X, Cushing KC, Bell HN, Raut C, Prabhu P, Chen VL, Halligan BD, Speliotes EK · PubMed 38200128

    Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of triglycerides to high-density lipoprotein cholesterol (TG:HDL-C) is a surrogate marker of IR. We conducted a genome-wide association study of the TG:HDL-C ratio in 402,398 Europeans within the UK Biobank. We identified 369 independent SNPs, of which 114 had a false discovery rate-adjusted P value < 0.05 in other genome-wide studies of IR making them high-confidence IR-associated loci. Seventy-two of these 114 loci have not been previously associated with IR. These 114 loci cluster into five groups upon phenome-wide analysis and are enriched for candidate genes important in insulin signaling, adipocyte physiology and protein metabolism. We created a polygenic-risk score from the high-confidence

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • refined carbohydrates and added sugars Moderate

    Refined carbohydrates and added sugars increase serum triglycerides; avoidance is important with genetic predisposition to elevated triglyceride-to-HDL ratio

    Limit refined grains, sugary beverages, and added sugars; target less than 10 percent of daily calories

Exercise

  • regular aerobic exercise Moderate

    Aerobic exercise improves triglyceride-to-HDL cholesterol ratio through reductions in triglycerides and increases in HDL cholesterol

    150 minutes moderate-intensity or 75 minutes vigorous-intensity aerobic exercise per week

Screening

  • triglycerides and HDL cholesterol levels Moderate

    rs111831594 G allele is associated with elevated triglyceride-to-HDL cholesterol ratio in a large population study

    Annual or biennial lipid panel screening