Expressive

rs111824905 - STX12

Magnitude 2.2 · 1 study on file

Reported associations

  • Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32541925

    ABSTRACT: We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ethnic meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program, DIAMANTE, Biobank Japan, and other studies. We report 568 associations, including 286 autosomal, 7 X chromosomal, and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D-associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD), and neuropathy. We investigated the genetic etiolo

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • refined carbohydrates and added sugars Moderate

    refined carbs and sugars raise glucose and insulin; minimization reduces diabetes risk in genetically predisposed individuals

    limit refined grains and added sugars to less than 5% of daily calories

  • whole grains and dietary fiber Moderate

    soluble fiber improves insulin sensitivity and glucose regulation in diabetes-susceptible individuals

    increase fiber to 25-30 grams daily through whole grains, legumes, and vegetables

Exercise

  • aerobic and resistance exercise Moderate

    exercise improves insulin sensitivity and reduces diabetes risk, particularly in genetically susceptible individuals

    150 minutes moderate-intensity aerobic activity per week plus 2-3 resistance sessions

Screening

  • fasting glucose and HbA1c screening Moderate

    rs111824905-C increases type 2 diabetes risk; regular glucose monitoring enables early detection and intervention

    check fasting glucose and HbA1c every 1-2 years starting at age 25