Expressive

rs111791351 - PLIN2

Magnitude 2.2 · 1 study on file

Reported associations

  • Trans-ethnic association study of blood pressure determinants in over 750,000 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 30578418

    ABSTRACT: In this trans-ethnic multi-omic study we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenome, and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in GWASs of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically-predicted gene expression of 840 genes in 45 tissues, and murine renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells. Editorial summary: Analysis of blood pressure data from

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Limit dietary sodium intake Moderate

    Sodium restriction reduces blood pressure; particularly relevant for genetic hypertension risk

    Target less than 2300 mg sodium per day

Discuss with your doctor

  • Cardiovascular risk assessment with blood pressure focus Moderate

    Genetic predisposition to hypertension may warrant individualized blood pressure management strategy

    Raise during regular checkup

Exercise

  • Regular aerobic exercise Moderate

    Aerobic exercise reduces blood pressure; directly addresses genetic hypertension predisposition

    150 minutes moderate intensity aerobic activity per week

Screening

  • Systolic blood pressure monitoring Moderate

    rs111791351 T allele associates with elevated systolic blood pressure (effect 0.205 mmHg per allele, p=4e-8, n=459777)

    Annual blood pressure measurement; establish baseline if not recently done