Expressive

rs111790405 - SORCS3

Magnitude 2.2 · 2 studies on file

Reported associations

  • Trans-ethnic association study of blood pressure determinants in over 750,000 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 30578418

    ABSTRACT: In this trans-ethnic multi-omic study we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenome, and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in GWASs of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically-predicted gene expression of 840 genes in 45 tissues, and murine renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells. Editorial summary: Analysis of blood pressure data from

  • Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits - Unknown journal (n.d.) · Unknown authors · PubMed 38689001

    ABSTRACT: Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10−8) from the largest single-stage blood pressure (BP) genome-wide association study to date (n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing top versus bottom deciles of polygenic risk scores (PRSs) reveals clinically meaningful differences in BP (16.9 mmHg systolic BP, 95% CI, 15.5-18.2 mmHg, P = 2.22 × 10−126) and more than a sevenfold higher odds of hypertension risk (odds ratio, 7.33; 95% CI, 5.54-9.70; P = 4.13 × 10−44) in an independent dataset. Adding PRS into hypertension-pre

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Blood pressure management strategy Moderate

    Genetic predisposition to elevated BP may warrant more proactive management approach

    Discuss whether genetic predisposition should influence BP management thresholds

Exercise

  • Aerobic exercise for blood pressure control Moderate

    Regular aerobic exercise reduces BP and is especially important given genetic elevation risk

    Aim for 150 minutes of moderate-intensity aerobic exercise weekly

Lifestyle

  • DASH diet and sodium reduction Moderate

    Genetic predisposition to elevated BP makes dietary intervention particularly important for risk reduction

    Adopt DASH diet pattern; limit sodium to less than 2300mg daily

Screening

  • Blood pressure monitoring starting age 30 High

    T allele at rs111790405 is associated with increased diastolic and systolic blood pressure across large cohorts

    Check blood pressure annually; more frequently if pre-hypertensive