rs111783937 - FGF12

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic loci implicated in meta-analysis of body shape in Africans. - Nutrition, metabolism, and cardiovascular diseases : NMCD (2022) · Nakabuye M, Kamiza AB, Soremekun O, Machipisa T, Cohen E, Pirie F, Nashiru O, Young E, Sandhu MS, Motala AA, Chikowore T, Fatumo S · PubMed 35461751

  Obesity is one of the leading causes of non-communicable diseases (NCD). Thus, NCD risk varies in obese individuals based on the location of their fat depots; while subcutaneous adiposity is protective, visceral adiposity increases NCD risk. Although, previously anthropometric traits have been used to quantify body shape in low-income settings, there is no consensus on how it should be assessed. Hence, there is a growing interest to evaluate body shape derived from the principal component analysis (PCA) of anthropometric traits; however, this is yet to be explored in individuals of African ancestry whose body shape is different from those of Europeans. We set out to capture body shape in its multidimensional structure and examine the association between genetic variants and body shape in i

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