rs111756027 - ADAMTS18

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association meta-analyses identified 1q43 and 2q32.2 for hip Ward's triangle areal bone mineral density - Unknown journal (n.d.) · Unknown authors · PubMed 27397699

  ABSTRACT: Aiming to identify genomic variants associated with osteoporosis, we performed a genome-wide association meta-analysis of bone mineral density (BMD) at Ward's triangle of the hip in 7,175 subjects from 6 samples. We performed in silico replications with femoral neck, trochanter, and inter-trochanter BMDs in 6,912 subjects from the Framingham heart study (FHS), and with forearm, femoral neck and lumbar spine BMDs in 32,965 subjects from the GEFOS summary results. Combining the evidence from all samples, we identified 2 novel loci for areal BMD: 1q43 (rs1414660, discovery p=1.20×10−8, FHS p=0.05 for trochanter BMD; rs9287237, discovery p=3.55×10−7, FHS p=9.20×10−3 for trochanter BMD, GEFOS p=0.02 for forearm BMD, nearest gene FMN2) and 2q32.2 (rs56346965, discovery p=7.48

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