Expressive

rs11175518 - LINC02471, LRRK2-DT

Magnitude 2.2 · 2 studies on file

Reported associations

  • Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis - Unknown journal (n.d.) · Unknown authors · PubMed 38632349

    ABSTRACT: We report a multi-ancestry genome-wide association study on liver cirrhosis and its associated endophenotypes, alanine aminotransferase (ALT) and γ-glutamyl transferase. Using data from 12 cohorts, including 18,265 cases with cirrhosis, 1,782,047 controls, up to 1 million individuals with liver function tests and a validation cohort of 21,689 cases and 617,729 controls, we identify and validate 14 risk associations for cirrhosis. Many variants are located near genes involved in hepatic lipid metabolism. One of these, PNPLA3 p.Ile148Met, interacts with alcohol intake, obesity and diabetes on the risk of cirrhosis and hepatocellular carcinoma (HCC). We develop a polygenic risk score that associates with the progression from cirrhosis to HCC. By focusing on prioritized genes from c

  • The power of genetic diversity in genome-wide association studies of lipids - Unknown journal (n.d.) · Unknown authors · PubMed 34887591

    ABSTRACT: Elevated blood lipid levels are heritable risk factors of cardiovascular disease with varying prevalence worldwide due to differing dietary patterns and medication use. Despite advances in prevention and treatment, particularly through the lowering of low-density lipoprotein cholesterol levels, heart disease remains the leading cause of death worldwide. Genome-wide association studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS have been conducted in European ancestry populations and may have missed genetic variants contributing to lipid level variation in other ancestry groups due to differences in allele frequencies, effect sizes, and linkage-disequilibr

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • lipid panel monitoring Moderate

    Genetic variant is associated with low-density lipoprotein cholesterol levels

    annual lipid panel; assess HDL, LDL, triglycerides and total cholesterol

  • liver enzyme monitoring Moderate

    Genetic variant is associated with elevated gamma-glutamyl transferase, marker of liver metabolic function

    annual liver function tests including GGT, AST, ALT

Diet

  • heart-healthy dietary pattern Moderate

    Reduced saturated fat and refined carbohydrate intake improves lipid profiles and cardiovascular outcomes

    follow Mediterranean or DASH diet; limit saturated fat to under 7 percent of calories

Exercise

  • regular aerobic exercise Moderate

    Physical activity lowers LDL cholesterol and improves cardiovascular function

    150 minutes moderate aerobic exercise weekly or 75 minutes vigorous