rs111751834 - ICA1-AS1 - NXPH1
Magnitude 2.2 · 1 study on file
Reported associations
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A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 26634245
ABSTRACT: Background Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed a genome-wide association study (GWAS) in 9919 current and former smokers in the COPDGene study (6659 non-Hispanic Whites [NHW] and 3260 African Americans [AA]) to identify associations with spirometric measures (post-bronchodilator FEV1 and FEV1/FVC). We also conducted meta-analysis of FEV1 and FEV1/FVC GWAS in the COPDGene, ECLIPSE, and GenKOLS cohorts (total n = 13,532). Results Among NHW in the COPDGene cohort, both measures of pulmonary function were significantly associated with SNPs at the 15q25 locus [containing CHRNA3/5, AGPHD1, IREB2, CHRNB4] (low
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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active and secondhand smoke exposure High
Genetic predisposition to reduced lung function makes smoking exposure particularly harmful
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minimize occupational and environmental respiratory irritants Moderate
Genetic predisposition to impaired lung function amplifies risk from respiratory irritant exposure
use appropriate respirator or choose roles avoiding dust, fumes, chemical exposure
Screening
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spirometry to establish baseline lung function Moderate
GWAS association indicates genetic predisposition to reduced FEV1 and FEV1/FVC ratio
baseline spirometry at age 35-40, repeat every 2-3 years if normal