Expressive

rs11174202 - TAFA2

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-Wide Association Study Reveals First Locus for Anorexia Nervosa and Metabolic Correlations - Unknown journal (n.d.) · Unknown authors · PubMed 28494655

    ABSTRACT: Objective To conduct a genome-wide association study (GWAS) of anorexia nervosa and to calculate genetic correlations with a series of psychiatric, educational, and metabolic phenotypes. Method Following uniform quality control and imputation using the 1000 Genomes Project (phase 3) in 12 case-control cohorts comprising 3,495 anorexia nervosa cases and 10,982 controls, we performed standard association analysis followed by a meta-analysis across cohorts. Linkage disequilibrium score regression (LDSC) was used to calculate genome-wide common variant heritability [ , partitioned heritability, and genetic correlations (rg)] between anorexia nervosa and other phenotypes. Results Results were obtained for 10,641,224 single nucleotide polymorphisms (SNPs) and insertion-deletion variant

  • Examination of the Shared Genetic Basis of Anorexia Nervosa and Obsessive-Compulsive Disorder - Unknown journal (n.d.) · Unknown authors · PubMed 30087453

    ABSTRACT: Anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) are often comorbid and likely to share genetic risk factors. Hence, we examine their shared genetic background using a cross-disorder GWAS meta-analysis of 3,495 AN cases, 2,688 OCD cases and 18,013 controls. We confirmed a high genetic correlation between AN and OCD (rg = 0.49 ± 0.13, p = 9.07×10−7) and a sizable SNP heritability (SNP h2 = 0.21 ± 0.02) for the cross-disorder phenotype. Although no individual loci reached genome-wide significance, the cross-disorder phenotype showed strong positive genetic correlations with other psychiatric phenotypes (e.g., rg = 0.36 with bipolar disorder and 0.34 with neuroticism) and negative correlations with metabolic phenotypes (e.g., rg = −0.25 with BMI and −0.20 with

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