Expressive

rs11172254 - KIF5A

Magnitude 2.2 · 1 study on file

Reported associations

  • Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32541925

    ABSTRACT: We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ethnic meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program, DIAMANTE, Biobank Japan, and other studies. We report 568 associations, including 286 autosomal, 7 X chromosomal, and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D-associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD), and neuropathy. We investigated the genetic etiolo

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Mediterranean or DASH dietary pattern Moderate

    G allele association indicates metabolic vulnerability; these patterns proven to reduce diabetes incidence

    Emphasize whole grains, legumes, vegetables, fish, olive oil; limit refined carbohydrates and added sugars

Exercise

  • regular aerobic and resistance exercise Moderate

    Physical activity improves insulin sensitivity; particularly important given increased genetic diabetes risk

    150 minutes moderate aerobic exercise plus 2 sessions resistance training per week minimum

Lifestyle

  • weight management to maintain BMI below 25 Moderate

    G allele indicates higher metabolic risk; weight loss of 5-10 percent significantly reduces diabetes incidence in high-risk populations

    Target BMI less than 25; if overweight, aim for 5-10 percent weight loss over 6 months

Screening

  • glucose and hemoglobin A1c screening starting early Moderate

    rs11172254 G allele associated with increased Type 2 diabetes risk; early detection enables prevention intervention

    Annual fasting glucose and HbA1c testing starting at age 30-35 or 10 years before first relative with diabetes