rs111696630 - LDHD - ZFP1
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency - Unknown journal (n.d.) · Unknown authors · PubMed 36267918
ABSTRACT: Summary Premature atrial contractions (PACs) are frequently observed on electrocardiograms and are associated with increased risks of atrial fibrillation (AF), stroke, and mortality. In this study, we aimed to identify genetic susceptibility loci for PAC frequency. We performed a genome-wide association study meta-analysis with PAC frequency obtained from ambulatory cardiac monitoring in 4,831 individuals of European ancestry. We identified a genome-wide significant locus at the SCN5A gene. The lead variant, rs7373862, located in an intron of SCN5A, was associated with an increase of 0.12 [95% CI 0.08-0.16] standard deviations of the normalized PAC frequency per risk allele. Among genetic variants previously associated with AF, there was a significant enrichment in concordance
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Cardiovascular risk assessment and PAC management strategy Moderate
Genetic association with PAC frequency suggests potential increased arrhythmia burden requiring individualized medical assessment and management plan.
Discuss findings with primary care physician or cardiologist to determine appropriate monitoring and intervention strategy.
Screening
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Baseline electrocardiogram and PAC documentation Moderate
SNP rs111696630 is associated with increased premature atrial contraction frequency; baseline assessment establishes individual arrhythmia burden.
Obtain baseline ECG to document PAC frequency; consider extended monitoring if symptoms are present.