Expressive

rs111693762 - FES

Magnitude 2.2 · 1 study on file

Reported associations

  • Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits - Unknown journal (n.d.) · Unknown authors · PubMed 39537608

    ABSTRACT: Several cardiovascular traits and diseases co-occur with Alzheimer's disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 16 genetic loci associated with both Alzheimer's and cardiovascular diseases. We prioritised rs11786896, which colocalised with Alzheimer's disease, atrial fibrillation and expression of PLEC in the heart left ventricle, and rs7529220, which colocalised with Alzheimer's disease, atrial fibrillation and expression of C1Q family genes. Single-cell RNA-sequencing data, co-expression network and protein-protein interaction analyses provided evidence for different mechanisms of PLEC, which is upregulated in left ventricular endothelium and cardiomyocyte

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • blood pressure risk management strategy Moderate

    Genetic predisposition to elevated systolic BP identified; warrants discussion of baseline BP status, family history, and whether preventive interventions are indicated.

    Discuss baseline BP, family history, and whether preventive interventions (lifestyle vs. pharmacotherapy) are indicated

Exercise

  • regular aerobic physical activity Moderate

    Aerobic exercise is proven to reduce systolic BP and is especially important for individuals with genetic predisposition to hypertension.

    150 minutes per week of moderate-intensity aerobic activity (e.g. brisk walking, jogging, cycling)

Lifestyle

  • adherence to low-sodium dietary pattern Moderate

    Genetic elevation of BP risk is particularly sensitive to dietary sodium intake; sodium restriction reduces BP in salt-sensitive genotypes.

    Maintain daily sodium intake below 2300 mg, aiming for under 1500 mg if prehypertension develops

Screening

  • systolic blood pressure Moderate

    T allele associates with elevated BP (p=5.00e-9, n=1.2M); FES expression reduced in vascular tissue including arteries.

    Measure blood pressure annually; more frequently if prehypertension or hypertension detected