rs111690247 - KDM2B
Magnitude 2.2 · 1 study on file
Reported associations
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Pleiotropic genetic architecture and novel loci for C-reactive protein levels - Unknown journal (n.d.) · Unknown authors · PubMed 36376304
ABSTRACT: C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes supporting common biological pathways between inflammation and metabolic traits. To identify novel pleiotropic loci, we perform multi-trait analysis of genome-wide association studies on C-reactive protein levels along with cardiometabolic traits, followed by a series of in silico analyses including colocalization, phenome-wide association studies and Mendelian randomization. We find 41 novel loci and 19 gene sets associated with C-reactive protein with various pleiotropic effects. Additionally, 41 variants colocalize between C-reactive protein and cardiometabolic risk factors and 12 of them display
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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C-reactive protein level baseline and periodic assessment Moderate
rs111690247 T allele associated with elevated C-reactive protein, a biomarker of systemic inflammation and cardiovascular risk
Baseline CRP measurement, with follow-up assessment every 1-2 years or per clinical indication
Discuss with your doctor
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Cardiovascular risk assessment given elevated CRP predisposition Moderate
Elevated CRP is an independent cardiovascular risk marker; genetic predisposition warrants discussion of overall risk profile and screening strategy
Discuss with healthcare provider at annual visit or when establishing care