rs11167801 - ARHGAP26

Magnitude 4.5 · 1 study on file

Reported associations

• Septic Shock: A Genomewide Association Study and Polygenic Risk Score Analysis. - Twin research and human genetics : the official journal of the International Society for Twin Studies (2021) · D'Urso S, Rajbhandari D, Peach E, de Guzman E, Li Q, Medland SE, Gordon SD, Martin NG, Ligthart S, Brown MA, Powell J, McArthur C, Rhodes A, Meyer J, Finfer S, Myburgh J, Blumenthal A, Cohen J, Venkatesh B, Cuellar-Partida G, Evans DM · PubMed 32755526

  Previous genetic association studies have failed to identify loci robustly associated with sepsis, and there have been no published genetic association studies or polygenic risk score analyses of patients with septic shock, despite evidence suggesting genetic factors may be involved. We systematically collected genotype and clinical outcome data in the context of a randomized controlled trial from patients with septic shock to enrich the presence of disease-associated genetic variants. We performed genomewide association studies of susceptibility and mortality in septic shock using 493 patients with septic shock and 2442 population controls, and polygenic risk score analysis to assess genetic overlap between septic shock risk/mortality with clinically relevant traits. One variant, rs948932

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