rs111671068 - RPL13AP25 - LINC02335

Magnitude 4.5 · 1 study on file

Reported associations

• Detailed stratified GWAS analysis for severe COVID-19 in four European populations - Unknown journal (n.d.) · Unknown authors · PubMed 35848942

  ABSTRACT: Abstract Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~0.9-Mb inversion polymorphism that creates two highl

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