rs111668452 - MARK2P14

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men - Unknown journal (n.d.) · Unknown authors · PubMed 32469969

  ABSTRACT: Background Carotid artery plaque is an established marker of subclinical atherosclerosis with pronounced sex-dimorphism. Here, we aimed to identify genetic variants associated with carotid plaque burden (CPB) and to examine potential sex-specific genetic effects on plaque sizes. Methods and results We defined six operationalizations of CPB considering plaques in common carotid arteries, carotid bulb, and internal carotid arteries. We performed sex-specific genome-wide association analyses for all traits in the LIFE-Adult cohort (n = 727 men and n = 550 women) and tested significantly associated loci for sex-specific effects. In order to identify causal genes, we analyzed candidate gene expression data for correlation with CPB traits and corresponding sex-specific effects. Further

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