rs111654000 - DENND4C
Magnitude 4.5 · 1 study on file
Reported associations
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Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program - Unknown journal (n.d.) · Unknown authors · PubMed 34446064
ABSTRACT: Background Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing. Methods The study sample was comprised of 7988 individuals of diverse ancestry. Common-variant and pathway analyses included an additional 13,257 individuals. We examined five complementary traits describing different aspects of sleep-disordered breathing: the apnea-hypopnea index, average oxyhemoglobin desaturation per event, average and minimum oxyhemoglobin saturation across the sleep episode, and the percentage of sleep with oxyhemoglobin saturat
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Sleep apnea evaluation Low
DENND4C rs111654000 A-allele carriers have lower apnea-hypopnea index in African-Americans; individuals without protective A allele show increased sleep apnea risk.
Consider polysomnography or home sleep study if symptomatic