rs111645190 - CYP2A6 - CYP2A7

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences - Unknown journal (n.d.) · Unknown authors · PubMed 28921760

  ABSTRACT: Background and aims The activity of CYP2A6, the major nicotine-inactivating enzyme, is measurable in smokers using the nicotine metabolite ratio (NMR; 3'hydroxycotinine/cotinine). Due to its role in nicotine clearance, the NMR is associated with smoking behaviours and response to pharmacotherapies. The NMR is highly heritable (~80%), and on average lower in African Americans (AA) versus Whites. We previously identified several reduce and loss-of-function CYP2A6 variants common in individuals of African descent. Our current aim was to identify novel genetic influences on the NMR in AA smokers using genome-wide approaches. Design Genome-wide association study (GWAS). Setting Multiple sites within Canada and the United States. Participants AA smokers from two clinical trials: Phar

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