rs111644425 - LZTS2

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study of patients with a severe major depressive episode treated with electroconvulsive therapy - Unknown journal (n.d.) · Unknown authors · PubMed 33483693

  ABSTRACT: Although large genome-wide association studies (GWAS) of major depressive disorder (MDD) have identified many significant loci, the SNP-based heritability remains notably low, which might be due to etiological heterogeneity in existing samples. Here, we test the utility of targeting the severe end of the MDD spectrum through genome-wide SNP genotyping of 2725 cases who received electroconvulsive therapy (ECT) for a major depressive episode (MDE) and 4035 controls. A subset of cases (n = 1796) met a narrow case definition (MDE occurring in the context of MDD). Standard GWAS quality control procedures and imputation were conducted. SNP heritability and genetic correlations with other traits were estimated using linkage disequilibrium score regression. Results were compared with

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