rs11162963 - ADH5P2 - HMGB1P18

Magnitude 2.2 · 1 study on file

Reported associations

• A Genome-Wide Association Study of Aging - Unknown journal (n.d.) · Unknown authors · PubMed 21782286

  ABSTRACT: Human longevity and healthy aging show moderate heritability (20-50%). We conducted a meta-analysis of genome-wide association studies from nine studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium for two outcomes: a) all-cause mortality and b) survival free of major disease or death. No single nucleotide polymorphism (SNP) was a genome-wide significant predictor of either outcome (p < 5 × 10−8). We found fourteen independent SNPs that predicted risk of death, and eight SNPs that predicted event-free survival (p < 10−5). These SNPs are in or near genes that are highly expressed in the brain (HECW2, HIP1, BIN2, GRIA1), genes involved in neural development and function (KCNQ4, LMO4, GRIA1, NETO1) and autophagy (ATG4C), and genes that are

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