Expressive

rs111599092 - NICN1 - RNA5SP130

Magnitude 4.5 · 2 studies on file

Reported associations

  • Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression - Unknown journal (n.d.) · Unknown authors · PubMed 41233554

    ABSTRACT: Major depressive disorder (MDD) is a common and heterogeneous disorder of complex etiology. Studying more homogeneous groups stratified according to clinical characteristics, such as age of onset, can improve the identification of the underlying genetic causes and lead to more targeted treatment strategies. We leveraged Nordic biobanks with longitudinal health registries to investigate differences in the genetic architectures of early-onset (eoMDD; n = 46,708 cases) and late-onset (loMDD; n = 37,168 cases) MDD. We identified 12 genomic loci for eoMDD and two for loMDD. Overall, the two MDD subtypes correlated moderately (genetic correlation, rg = 0.58) and differed in their genetic correlations with related traits. These findings suggest that eoMDD and loMDD have part

  • Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function - Unknown journal (n.d.) · Unknown authors · PubMed 29844566

    ABSTRACT: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10−8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function

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