rs111597524 - RPLP0P3 - NFKBIA

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study in a Korean population identifies six novel susceptibility loci for rheumatoid arthritis - Unknown journal (n.d.) · Unknown authors · PubMed 32723749

  ABSTRACT: Objective Genome-wide association studies (GWAS) in rheumatoid arthritis (RA) have discovered over 100 RA loci, explaining patient-relevant RA pathogenesis but showing a large fraction of missing heritability. As a continuous effort, we conducted GWAS in a large Korean RA case-control population. Methods We newly generated genome-wide variant data in two independent Korean cohorts comprising 4068 RA cases and 36 487 controls, followed by a whole-genome imputation and a meta-analysis of the disease association results in the two cohorts. By integrating publicly available omics data with the GWAS results, a series of bioinformatic analyses were conducted to prioritise the RA-risk genes in RA loci and to dissect biological mechanisms underlying disease associations. Results We i

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