rs111591235 - DNAH5

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association studies in Japanese women identified genetic loci associated with wrinkles and sagging. - Experimental dermatology (2022) · Okuno R, Inoue Y, Hasebe Y, Igarashi T, Kawagishi-Hotta M, Yamada T, Hasegawa S · PubMed 35587111

  Wrinkles and sagging are caused by various factors, such as ultraviolet rays; however, recent findings demonstrated that some individuals are genetically predisposed to these phenotypes of skin aging. The contribution of single nucleotide polymorphisms (SNPs) to the development of wrinkles and sagging has been demonstrated in genome-wide association studies (GWAS). However, these findings were mainly obtained from European and Chinese populations. Limited information is currently available on the involvement of SNPs in the development of wrinkles and sagging in a Japanese population. Therefore, we herein performed GWAS on wrinkles at the outer corners of the eyes and nasolabial folds in 1041 Japanese women. The results obtained revealed that 5 SNPs (19p13.2: rs2303098 (p = 3.39 × 10

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