rs11159086 - ISCA2

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic Analysis of Advanced Glycation End Products in the DHS MIND Study - Unknown journal (n.d.) · Unknown authors · PubMed 26915486

  ABSTRACT: Advanced glycation end-products (AGEs) are a diverse group of molecules produced by the non-enzymatic addition of glucose to proteins, lipids, and nucleic acids. AGE levels have been associated with hyperglycemia and diabetic complications, especially in animal models, but less clearly in human studies. We measured total serum AGEs using an enzyme linked immunosorbant assay (ELISA) in 506 subjects from 246 families in the Diabetes Heart Study (DHS)/DHS MIND Study (n= 399 type 2 diabetes(T2D)-affected). Single nucleotide polymorphisms (SNPs) in several candidate genes, including known AGE receptors, were tested for their influence on circulating AGE levels. The genetic analysis was expanded to include an exploratory genome-wide association study (GWAS) and exome chip analysis of A

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