rs11158907 - SIPA1L1

Magnitude 2.2 · 1 study on file

Reported associations

• ALDH2 is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample - Unknown journal (n.d.) · Unknown authors · PubMed 24277619

  ABSTRACT: Alcohol dependence (AD) is a moderately heritable phenotype with a small number of known risk genes mapped via linkage or candidate gene studies. We considered 313 males from among 600 members of documented, extended pedigrees in which AD segregates collected in Northern Hunan Province, China. A joint analysis of both males and females could not be performed as the difference in alcohol consumption variance was too large. Genome-wide association analyses were performed for approximately 300,000 single nucleotide polymorphisms (SNPs). Significant associations found in the ALDH2 region for AD (minimum p = 4.73×10-8) and two AD-related phenotypes: flushing response (minimum p = 4.75×10-26) and maximum drinks in a 24-hour period (minimum p = 1.54×10-16). Association of previous ca

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