Expressive

rs11155072 - LINC01625 - ATP5PBP6

Magnitude 2.2 · 2 studies on file

Reported associations

  • Pleiotropic genetic architecture and novel loci for C-reactive protein levels - Unknown journal (n.d.) · Unknown authors · PubMed 36376304

    ABSTRACT: C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes supporting common biological pathways between inflammation and metabolic traits. To identify novel pleiotropic loci, we perform multi-trait analysis of genome-wide association studies on C-reactive protein levels along with cardiometabolic traits, followed by a series of in silico analyses including colocalization, phenome-wide association studies and Mendelian randomization. We find 41 novel loci and 19 gene sets associated with C-reactive protein with various pleiotropic effects. Additionally, 41 variants colocalize between C-reactive protein and cardiometabolic risk factors and 12 of them display

  • A genetic map of human metabolism across the allele frequency spectrum - Unknown journal (n.d.) · Unknown authors · PubMed 41044249

    ABSTRACT: Genetic studies of human metabolism have been limited in scale and allelic breadth. Here we provide a data-driven map of the genetic regulation of circulating small molecules and lipoprotein characteristics (249 traits) measured using proton nuclear magnetic resonance spectroscopy across the allele frequency spectrum in ~450,000 individuals. Trans-ancestral meta-analyses identify 29,824 locus-metabolite associations mapping to 753 regions with effects largely consistent between men and women and large ancestral groups represented in UK Biobank. We observe and classify extreme genetic pleiotropy, identify regulators of lipid metabolism, and assign effector genes at >100 loci through rare-to-common allelic series. We propose roles for genes less established in metabolic control (

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • fasting lipid panel with VLDL and triglycerides High

    rs11155072 A allele is associated with elevated triglycerides (p=5e-30, n=361194) and free cholesterol in large VLDL particles (p=4e-39, n=241027)

    annual or semi-annual fasting lipid panel

Diet

  • limit alcohol consumption Moderate

    alcohol increases triglyceride synthesis; particularly relevant for rs11155072 A allele carriers with elevated baseline triglycerides

    limit to moderate amounts: one drink daily for women, two for men

  • refined carbohydrates and added sugars Moderate

    refined carbohydrates increase hepatic triglyceride production; limiting intake helps manage elevated triglycerides associated with rs11155072 A allele

    reduce refined carbohydrate intake to less than 25 percent of daily calories

  • soluble fiber from whole grains and legumes Moderate

    soluble fiber reduces triglyceride synthesis; particularly important for rs11155072 A carriers with elevated baseline triglycerides

    target 10-15g daily soluble fiber from oats, beans, vegetables

Exercise

  • regular aerobic exercise Moderate

    aerobic exercise increases triglyceride clearance and improves VLDL metabolism; particularly beneficial for rs11155072 A allele carriers

    150 minutes moderate-intensity aerobic activity per week

Screening

  • cardiovascular disease risk assessment High

    elevated triglycerides and VLDL cholesterol associated with rs11155072 A allele increase cardiovascular disease risk

    discuss 10-year ASCVD risk score with physician if age 40-75