rs11154369 - RPS4XP9 - RSPO3
Magnitude 2.2 · 1 study on file
Reported associations
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Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults - Unknown journal (n.d.) · Unknown authors · PubMed 39048560
ABSTRACT: Elevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations. Despite strong genetic correlations between populations, we identified appreciably higher heritability and larger variant effect sizes in Chinese compared with European or Japanese ancestry populations. Using instruments derived from these GWAS, multivariable Mendelian randomisation demonstrated
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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blood pressure monitoring Moderate
This variant is significantly associated with systolic and mean arterial pressure, indicating genetic predisposition to higher blood pressure.
Check blood pressure regularly; discuss screening frequency with your healthcare provider.