rs11154334 - NCOA7
Magnitude 2.2 · 1 study on file
Reported associations
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Trans-ethnic association study of blood pressure determinants in over 750,000 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 30578418
ABSTRACT: In this trans-ethnic multi-omic study we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenome, and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in GWASs of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically-predicted gene expression of 840 genes in 45 tissues, and murine renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells. Editorial summary: Analysis of blood pressure data from
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic cardiovascular risk with healthcare provider High
Genetic risk factor for systolic blood pressure elevation; HEY2 expression changes affect vascular development
Discuss rs11154334 status, family hypertension history, and individualized BP management strategy
Screening
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Systolic blood pressure monitoring from age 30 High
rs11154334 risk allele strongly associated with elevated systolic blood pressure across 459,777 individuals
Check blood pressure at least annually; discuss screening schedule with healthcare provider