Expressive

rs11154027 - RNU4-35P - RNU4-76P

Magnitude 2.2 · 3 studies on file

Reported associations

  • Genomic Prediction of Tendinopathy Risk in Elite Team Sports. - International journal of sports physiology and performance (2023) · Rodas G, Osaba L, Arteta D, Pruna R, Fernández D, Lucia A · PubMed 31615970

    The authors investigated the association between risk of tendinopathies and genetic markers in professional team sports. The authors studied 363 (mean [SD]; 25 [6] y, 89% male) elite players (soccer, futsal, basketball, handball, and roller hockey) from a top-level European team (FC Barcelona, Spain). Of 363, 55% (cases) had experienced 1+ episodes of tendinopathy during 2008-2018 and 45% (controls) remained injury free. The authors first examined the association between single-nucleotide polymorphisms (SNPs) and tendinopathy risk in a hypothesis-free case-control genome-wide association study (495,837 SNPs) with additional target analysis of 58 SNPs that are potential candidates to influence tendinopathy risk based on the literature. Thereafter, the authors augmented the SNP set by perfo

  • Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders - Unknown journal (n.d.) · Unknown authors · PubMed 23583979

    ABSTRACT: Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and red

  • Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk - Unknown journal (n.d.) · Unknown authors · PubMed 28135244

    ABSTRACT: Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. Combined with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine appr

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic predisposition to tendinopathy and prevention strategies Moderate

    rs11154027 association with tendinopathy (OR 2.11, p<1e-6) indicates increased genetic risk; personalized prevention plan can reduce injury incidence

    Discuss with healthcare provider: genetic risk assessment, screening recommendations, and evidence-based prevention strategies specific to your activity level

Exercise

  • Eccentric strengthening exercises for tendon resilience Moderate

    rs11154027 risk variant is associated with increased tendinopathy susceptibility; eccentric loading builds tendon strength and resilience

    Perform eccentric strengthening exercises (e.g., eccentric calf raises) 3 times per week, 15-20 repetitions, with 2-3 day recovery between sessions

Lifestyle

  • Progressive training load management Moderate

    rs11154027 carriers show increased tendinopathy risk; controlled, gradual increases in training load reduce overuse injury risk

    Follow 10 percent rule: limit weekly increases in training volume or intensity to 10 percent; include adequate rest days between intense training sessions

Screening

  • Tendon health assessment and early symptom monitoring Moderate

    rs11154027 is associated with 2.11-fold increased tendinopathy risk; early detection allows intervention before symptoms worsen

    Annual physical examination focusing on tendon pain, stiffness, or swelling; report new tendon symptoms to healthcare provider promptly