rs11148643 - LINC00355 - LGMNP1

Magnitude 2.0 · 1 study on file

Reported associations

• A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis - Unknown journal (n.d.) · Unknown authors · PubMed 21156761

  ABSTRACT: Background Rheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA). Until now, data from genome-wide association studies (GWAS) have only been published from ACPA-positive subsets of RA or from studies that have not separated the two subsets. The aim of the current study is to provide and compare GWAS data for both subsets. Methods and results GWAS using the Illumina 300K chip was performed for 774 ACPA-negative patients with RA, 1147 ACPA-positive patients with RA and 1079 controls from the Swedish population-based case-control study EIRA. Imputation was performed which allowed comparisons using 1 723 056 single nucleotide polymorphisms (SNPs). No SNP achieved genome-wide significan

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