rs11148252 - VPS36

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias - Unknown journal (n.d.) · Unknown authors · PubMed 25188341

  ABSTRACT: Alzheimer's disease (AD) and related dementias are a major public health challenge and present a therapeutic imperative for which we need additional insight into molecular pathogenesis. We performed a genome-wide association study and analysis of known genetic risk loci for AD dementia using neuropathologic data from 4,914 brain autopsies. Neuropathologic data were used to define clinico-pathologic AD dementia or controls, assess core neuropathologic features of AD (neuritic plaques, NPs; neurofibrillary tangles, NFTs), and evaluate commonly co-morbid neuropathologic changes: cerebral amyloid angiopathy (CAA), Lewy body disease (LBD), hippocampal sclerosis of the elderly (HS), and vascular brain injury (VBI). Genome-wide significance was observed for clinico-pathologic AD dementi

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