rs1114761 - GML
Magnitude 2.2 · 1 study on file
Reported associations
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Translational genomics of osteoarthritis in 1,962,069 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 40205036
ABSTRACT: Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent associations, 513 of which have not been previously reported. Using single-cell multiomics data, we identify signal enrichment in embryonic skeletal development pathways. We integrate orthogonal lines of evidence, including transcriptome, proteome and epigenome profiles of primary joint tiss
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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anti-inflammatory dietary pattern Moderate
Dietary inflammatory markers associate with OA progression; reducing inflammatory foods supports joint health.
emphasize fatty fish, vegetables, fruits; limit refined grains and processed foods
Exercise
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low-impact aerobic exercise High
Regular movement maintains joint function and cartilage health while avoiding mechanical stress.
150 minutes per week of moderate-intensity low-impact activity like walking, swimming, or cycling
Lifestyle
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maintain healthy weight High
Excess body weight increases mechanical loading and inflammatory stress on joints.
aim for BMI less than 25 or body composition goal per healthcare provider
Screening
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joint health screening starting in 40s Moderate
Early detection of osteoarthritis enables intervention before progression becomes limiting.
annual assessment of joint pain, stiffness, and function after age 40