rs11146399 - LINC02870 - LINC01165

Magnitude 4.5 · 1 study on file

Reported associations

• The genetic architecture of language functional connectivity. - NeuroImage (2022) · Mekki Y, Guillemot V, Lemaître H, Carrión-Castillo A, Forkel S, Frouin V, Philippe C · PubMed 34929384

  Language is a unique trait of the human species, of which the genetic architecture remains largely unknown. Through language disorders studies, many candidate genes were identified. However, such complex and multifactorial trait is unlikely to be driven by only few genes and case-control studies, suffering from a lack of power, struggle to uncover significant variants. In parallel, neuroimaging has significantly contributed to the understanding of structural and functional aspects of language in the human brain and the recent availability of large scale cohorts like UK Biobank have made possible to study language via image-derived endophenotypes in the general population. Because of its strong relationship with task-based fMRI (tbfMRI) activations and its easiness of acquisition, resting-s

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