rs11142701 - TRPM3
Magnitude 2.2 · 1 study on file
Reported associations
-
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction - Unknown journal (n.d.) · Unknown authors · PubMed 38839884
ABSTRACT: Restless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded by delayed diagnosis and insufficient treatment. To advance disease prediction and find new entry points for therapy, we performed meta-analyses of genome-wide association studies in 116,647 individuals with RLS (cases) and 1,546,466 controls of European ancestry. The pooled analysis increased the number of risk loci eightfold to 164, including three on chromosome X. Sex-specific meta-analyses revealed largely overlapping genetic predispositions of the sexes (rg = 0.96). Locus annotation prioritized druggable genes such as glutamate receptors 1 and 4, and Mendelian randomization indicated RLS as a causal risk factor for diabetes. Machine learning approaches combining genetic and nongen
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
-
fresh fruit intake Moderate
MR analysis shows fresh fruit consumption causally reduces RLS risk
increase daily fresh fruit servings to 2-3 per day
Discuss with your doctor
-
TRPM3-targeted pharmacotherapy options for RLS Moderate
TRPM3 is a top-scoring gene for RLS; primidone targets TRPM3
if RLS symptoms develop, discuss TRPM3-targeting drugs like primidone with physician
Lifestyle
-
stress management and tension reduction Moderate
MR analysis indicates emotional tension causally increases RLS risk
practice daily stress reduction (meditation, yoga, or similar) for 15-30 minutes
Screening
-
restless legs syndrome symptom monitoring High
rs11142701 is strongly associated with RLS risk (p=6.01e-15)
discuss RLS screening with physician; symptoms include uncomfortable sensations in legs when resting