Expressive

rs111423688 - PLEKHM1

Magnitude 4.5 · 2 studies on file

Reported associations

  • Large-scale brainstem neuroimaging and genetic analyses provide new insights into the neuronal mechanisms of hypertension - Unknown journal (n.d.) · Unknown authors · PubMed 39663699

    ABSTRACT: Summary While brainstem regions are central regulators of blood pressure, the neuronal mechanisms underlying their role in hypertension remain poorly understood. Here, we investigated the structural and genetic relationships between global and regional brainstem volumes and blood pressure. We used magnetic resonance imaging data from n = 32,666 UK Biobank participants, and assessed the association of volumes of the whole brainstem and its main regions with blood pressure. We applied powerful statistical genetic tools, including bivariate causal mixture modeling (MiXeR) and conjunctional false discovery rate (conjFDR), to non-overlapping genome-wide association studies of brainstem volumes (n = 27,034) and blood pressure (n = 321,843) in the UK Biobank cohort. We observed nega

  • A large-scale genome-wide cross-trait analysis for the effect of COVID-19 on female-specific cancers - Unknown journal (n.d.) · Unknown authors · PubMed 37636041

    ABSTRACT: Summary Little is known regarding the long-term adverse effects of COVID-19 on female-specific cancers, nor the shared genetic influences underlying these conditions. We performed a comprehensive genome-wide cross-trait analysis to investigate the shared genetic architecture between COVID-19 (infection, hospitalization, and critical illness) with three female-specific cancers (breast cancer (BC), epithelial ovarian cancer (EOC), and endometrial cancer (EC)). We identified significant genome-wide genetic correlations with EC for both hospitalization ( = 0.19, p = 0.01) and critical illness ( = 0.29, p = 3.00 × 10−4). Mendelian randomization demonstrated no valid association of COVID-19 with any cancer of interest, except for suggestive associations of genetically predicte

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