Expressive

rs11138311 - TLE4

Magnitude 2.2 · 2 studies on file

Reported associations

  • Using Mendelian randomization to evaluate the causal relationship between serum C-reactive protein levels and age-related macular degeneration. - European journal of epidemiology (2020) · Han X, Ong JS, An J, Hewitt AW, Gharahkhani P, MacGregor S · PubMed 31900758

    Serum C-reactive protein (CRP), an important inflammatory marker, has been associated with age-related macular degeneration (AMD) in observational studies; however, the findings are inconsistent. It remains unclear whether the association between circulating CRP levels and AMD is causal. We used two-sample Mendelian randomization (MR) to evaluate the potential causal relationship between serum CRP levels and AMD risk. We derived genetic instruments for serum CRP levels in 418,642 participants of European ancestry from UK Biobank, and then conducted a genome-wide association study for 12,711 advanced AMD cases and 14,590 controls of European descent from the International AMD Genomics Consortium. Genetic variants which predicted elevated serum CRP levels were associated with advanced AMD (o

  • A saturated map of common genetic variants associated with human height - Unknown journal (n.d.) · Unknown authors · PubMed 36224396

    ABSTRACT: Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • C-reactive protein level baseline screening Moderate

    rs11138311 T allele associates with elevated CRP, a marker of systemic inflammation and cardiovascular risk

    Baseline CRP test; repeat annually or as clinically indicated

Discuss with your doctor

  • Cardiovascular risk assessment given CRP association Moderate

    Higher baseline CRP from genetic factors warrants personalized discussion of cardiovascular risk profile and monitoring strategy

Lifestyle

  • Anti-inflammatory diet and regular aerobic exercise Moderate

    Mediterranean diet and aerobic exercise reduce CRP and cardiovascular risk, potentially offsetting genetic predisposition to elevated CRP

    Mediterranean diet pattern; 150 minutes moderate aerobic exercise per week