Expressive

rs11135897 - EBF2

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Adequate dietary fiber intake Moderate

    Chronic straining during constipation elevates intra-abdominal pressure, increasing hernia risk

    25-35 grams per day; 8+ glasses water daily

Discuss with your doctor

  • Discuss inguinal hernia genetic risk and prevention Moderate

    rs11135897-T allele confers significant hernia susceptibility; informed discussion enables preventive planning

Lifestyle

  • Maintain healthy BMI Moderate

    Elevated body weight increases intra-abdominal pressure, a known risk factor for hernia formation in genetically susceptible individuals

    Target BMI 18.5-24.9

  • Use proper lifting mechanics Moderate

    Heavy lifting with poor form increases intra-abdominal pressure, a primary mechanical risk factor for hernia development

    When lifting: straight back, bent knees, load close to body

Screening

  • Inguinal hernia screening starting in early adulthood Moderate

    T allele at rs11135897 increases inguinal hernia risk 1.15-fold per copy

    Clinical examination annually or when symptoms develop