Expressive

rs11135872 - CDCA2 - EBF2

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • inguinal hernia risk awareness and screening Moderate

    rs11135872 associated with 9% increased odds of inguinal hernia per GWAS

Exercise

  • core strength and abdominal conditioning Moderate

    Strong abdominal muscles provide structural support to prevent wall weakness

    3-4 times per week, 15-30 minute core strengthening sessions

Lifestyle

  • maintain healthy body weight Moderate

    Excess weight increases intra-abdominal pressure, elevating hernia risk

    Target BMI under 25 kg/m2 or per physician guidance

  • proper lifting mechanics and avoid heavy lifting Moderate

    Heavy lifting and straining elevate intra-abdominal pressure

    Use correct form, avoid repetitive heavy loads, brace core when lifting