rs111329014 - MYO9A
Magnitude 2.2 · 1 study on file
Reported associations
-
Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Unknown journal (n.d.) · Unknown authors · PubMed 40436827
ABSTRACT: Genome-wide association studies (GWAS) have predominantly focused on European ancestry populations, limiting biological discoveries across diverse populations. Here we report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 previously unreported genetic loci in KCPS2, including an association between thyroid-stimulating hormone and CD36. Meta-analysis with the Korean Genome and Epidemiology Study, Biobank Japan, Taiwan Biobank, and UK Biobank identified 4588 loci that were not significant in any contributing GWAS. We describe differences in genetic architectures across these East Asian and European samples. We also highlight East Asian specific associations, including a known pleiotrop
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
-
serum uric acid level Moderate
This variant is significantly associated with elevated serum uric acid levels
Annual testing, more frequently if elevated (>6.5 mg/dL)
Diet
-
limit high-purine foods Moderate
Dietary purines are metabolized to uric acid; restriction reduces serum levels
Limit red meat, organ meats, shellfish, high-fructose drinks, alcohol
Lifestyle
-
daily water intake for uric acid management Moderate
Adequate hydration increases urinary excretion of uric acid
Drink 2-3 liters of water daily, adjust for activity level