rs111326206 - PLS1 - TRPC1
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores - Unknown journal (n.d.) · Unknown authors · PubMed 31164008
ABSTRACT: Objective: Over 90% of suicide attempters have a psychiatric diagnosis, however twin and family studies suggest that the genetic etiology of suicide attempt (SA) is partially distinct from that of the psychiatric disorders themselves. Here, we present the largest genome-wide association study (GWAS) on suicide attempt using major depressive disorder (MDD), bipolar disorder (BIP) and schizophrenia (SCZ) cohorts from the Psychiatric Genomics Consortium. Method: Samples comprise 1622 suicide attempters and 8786 non-attempters with MDD, 3264 attempters and 5500 non-attempters with BIP and 1683 attempters and 2946 non-attempters with SCZ. SA GWAS were performed by comparing attempters to non-attempters in each disorder followed by meta-analyses across disorders. Polygenic risk scoring
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Suicide attempt risk in major depressive disorder Moderate
rs111326206 C allele carriers show significantly increased association with suicide attempts in MDD (OR 1.613, p-value 7e-7)
Discuss genetic finding with psychiatrist and establish enhanced monitoring plan
Screening
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Enhanced mental health screening for suicide risk Moderate
Genetic association with increased suicide attempt risk in individuals with major depressive disorder warrants enhanced screening
Annual or more frequent suicide risk assessment if carrying C allele and have MDD diagnosis