rs111325002 - MTHFD2P1 - HNRNPKP4

Magnitude 2.0 · 1 study on file

Reported associations

• Genomewide association study of cocaine dependence and related traits: FAM53B identified as a risk gene - Unknown journal (n.d.) · Unknown authors · PubMed 23958962

  ABSTRACT: We report a GWAS for cocaine dependence (CD) in three sets of African- and European-American subjects (AAs and EAs, respectively), to identify pathways, genes, and alleles important in CD risk. The discovery GWAS dataset (n=5,697 subjects) was genotyped using the Illumina OmniQuad microarray (890,000 analyzed SNPs). Additional genotypes were imputed based on the 1000 Genomes reference panel. Top-ranked findings were evaluated by incorporating information from publicly available GWAS data from 4,063 subjects. Then, the most significant GWAS SNPs were genotyped in 2,549 independent subjects. We observed one genomewide-significant (GWS) result: rs7086629 at the FAM53B ("family with sequence similarity 53, member B") locus. This was supported in both AAs and EAs; p-value (meta-an

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